Regulation of early growth response 2 expression by secreted frizzled related protein 1

Secreted frizzled-related protein 1 (SFRP1) expression is down-regulated in a multitude of cancers, including breast cancer. Loss of Sfrp1 also exacerbates weight gain as well as inflammation. Additionally, loss of SFRP1 enhances TGF-β signaling and the downstream MAPK pathway. | Regulation of early growth response 2 expression by secreted frizzled related protein 1

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