Precision oncology using a limited number of cells: Optimization of whole genome amplification products for sequencing applications

Sequencing analysis of circulating tumor cells (CTCs) enables “liquid biopsy” to guide precision oncology strategies. However, this requires low-template whole genome amplification (WGA) that is prone to errors and biases from uneven amplifications. | Precision oncology using a limited number of cells Optimization of whole genome amplification products for sequencing applications

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