A type I combi-targeting approach for the design of molecules with enhanced potency against BRCA1/2 mutant- and O6-methylguanine-DNA methyltransferase (mgmt)- expressing tumour cells

Mutations of the DNA repair proteins BRCA1/2 are synthetically lethal with the DNA repair enzyme poly(ADP-ribose) polymerase (PARP), which when inhibited, leads to cell death due to the absence of compensatory DNA repair mechanism. | A type I combi-targeting approach for the design of molecules with enhanced potency against BRCA1 2 mutant- and O6-methylguanine-DNA methyltransferase mgmt - expressing tumour cells

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