Angiopoietin-1 deficiency increases tumor metastasis in mice

Angipoietin-1 activation of the tyrosine kinase receptor Tek expressed mainly on endothelial cells leads to survival and stabilization of endothelial cells. Studies have shown that Angiopoietin-1 counteracts permeability induced by a number of stimuli. | Angiopoietin-1 deficiency increases tumor metastasis in mice

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