A high rate of glycolysis leading to elevated lactate content has been linked to poor clinical outcomes in patients with head and neck and cervical cancer treated with radiotherapy. Although the biological explanation for this relationship between lactate and treatment response remains unclear, there is a continued interest in evaluating strategies of targeting metabolism to enhance the effectiveness of radiotherapy. | Metabolic targeting of HIF-dependent glycolysis reduces lactate increases oxygen consumption and enhances response to high-dose single-fraction radiotherapy in hypoxic solid tumors
