Retinoblastoma (Rb) is the most common primary intraocular tumor in children. Local treatment of the intraocular disease is usually effective if diagnosed early; however advanced Rb can metastasize through routes that involve invasion of the choroid, sclera and optic nerve or more broadly via the ocular vasculature. | Inhibition of MMP-2 and MMP-9 decreases cellular migration and angiogenesis in in vitro models of retinoblastoma