Depletion of p21-activated kinase 1 upregulates the immune system of APCΔ14/+ mice and inhibits intestinal tumorigenesis

P21-activated kinase 1 (PAK1) stimulates growth and metastasis of colorectal cancer (CRC) through activation of multiple signalling pathways. Up-regulation of CRC stem cell markers by PAK1 also contributes to the resistance of CRC to 5-fluorouracil. | Depletion of p21-activated kinase 1 upregulates the immune system of APCΔ14 mice and inhibits intestinal tumorigenesis

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2    7    1    09-05-2021