P21-activated kinase 1 (PAK1) stimulates growth and metastasis of colorectal cancer (CRC) through activation of multiple signalling pathways. Up-regulation of CRC stem cell markers by PAK1 also contributes to the resistance of CRC to 5-fluorouracil. | Depletion of p21-activated kinase 1 upregulates the immune system of APCΔ14 mice and inhibits intestinal tumorigenesis