A field experiment was conducted during kharif 2012 to evaluate the efficacy of different pre and post emergence herbicides in direct seeded rice. The chemical treatments included two pre-emergence herbicides namely pendimethalin 1000 g/ha and oxadiargyl 100 g/ha and four post-emergence herbicides viz. bispyribac-sodium 25 g/ha, fenoxaprop 67 g/ha, ethoxysulfuron g/ha and chlorimuron-ethyl +metsulfuron-methyl RM 4 g/ha at 25 DAS. Weed free and weedy check were also included. Among chemical treatments, sequential application of pendimethalin 1000 g/ha fb bispyribac-sodium 25 g/ha and chlorimuron-ethyl+ metsulfuron-methyl RM 4 g/ha produces minimum density of Echinochloa glabrescens, Cyperus spp. and Ammania spp. at 45 DAS which was statistically at par with weed free. | Bio-efficacy of sequential application of herbicides on weeds and yield in direct seeded rice Oryza sativa