A four years age cow was presented to the Veterinary Clinical Complex (VCC), College of Veterinary Science, Rajendranagar, Hyderabad with the history of decreased appetite, depression, decreased milk yield and with swollen mammary gland for four days. General clinical examination revealed increased body temperature of 1040 F and palpation of udder revealed swollen udder and animal is feeling pain on touch. Milk was stripped for testing and found flakes and the colour of the milk is yellowish brown. Complete blood examination showed increased total erythrocyte count and neutrophils, and decreased concentration of lymphocytes. Further milk sample was tested for cultural and antibiotic sensitivity test and was diagnosed as clinical mastitis developed due to Staphylococcus aureus. Treatment with both topical and parenteral administration of anti-inflammatory, antibiotics and other supportive drugs was given for seven days continuously and cow recovered completely with alleviation of clinical signs and normal milk secretion. | A case study of clinical mastitis in a cow