The use of medaka fish as a candidate animal model has been started which has similarities with the Zebra fish that was developed as an animal model. Sulawesi medaka fish (Oryzias celebensis) is a type of medaka fish that are endemic in the region of South Sulawesi. This research aims to observe the histology of anterior gut of Sulawesi medaka fish. Histological study on the anterior gut of Sulawesi medaka fish using buccal cavity and oesophagus organs. Histological observation showed that the mouth and buccal cavity are shared by the respiratory and digestive systems. | Micromorphological observation of the anterior gut of Sulawesi medaka fish Oryzias celebensis