Treatment with a combination of drugs has been used as an approach to overcome bacterial resistance. The combination of compounds can have synergistic, addictive, or antagonistic effects. The synergistic effect of antibacterial compounds combined is expected to increase antibacterial activity so as to prevent the occurrence of resistance. Betel (Piper betle L.) and red betel (Piper crocatum Ruiz & Pav.) leaves have antibacterial activity. This study compared the antibacterial activity of betel, red betel, to the combinations of betel and red betel. | Antagonistic antibacterial effect of betel and red betel combination against gram-positive and gram-negative bacteria
