In mammals, skin is the largest of the body's organs which provides an immediate and excellent barrier between the internal tissues and external environment. Dendritic cells are antigen presenting cells which regulate the immune responses. The present study, aimed to describe the morphology and distribution of dendritic cells present among the skin of cattle, buffalo, sheep and goat. Dendritic cells were stained using Osmium tetroxide solution. The dendritic cells were mostly located in the basal layer at epidermis except small ruminats wherein the cells were mostly in the dermis. | Morphology distribution and functional significance of dendritic cells DCs in the skin of domestic animals