The pharmacokinetic of levofloxacin (4 mg/kg) was studied following intravenous administration of levofloxacin in ketoprofen (3 mg/kg) treated and febrile (Lipopolysaccharide induced) goats. The concentration of levofloxacin in plasma was detected by using High Performance Liquid Chromatography. No significant changes were reported in pharmacokinetic parameters following co-administration of levofloxacin with ketoprofen. While under febrile state, significant increase in area under plasma curve and decrease in total body clearance were observed. Integrating the pooled pharmacokinetic data generated from the present study, levofloxacin via intravenous administration (4 mg/kg) repeated at 12 h interval is sufficient to maintain plasma concentration above the g/mL MIC for most of the gram-positive and gram-negative microorganisms. | Effect of ketoprofen co-administration and febrile state on pharmacokinetics of levofloxacin in goats following intravenous administration
