The loss of a single copy of adenomatous polyposis coli (Apc) in leucine-rich repeats and immunoglobulin-like domains 1 (Lrig1)-expressing colonic progenitor cells induces rapid growth of adenomas in mice with high penetrance and multiplicity. | Epigenetic loss of heterozygosity of Apc and an inflammation associated mutational signature detected in Lrig1 driven murine colonic adenomas