Whole brain radiation therapy (WBRT) is the standard therapy for multiple brain metastases. However, WBRT has a poor local tumor control and is associated with a decline in neurocognitive function (NCF). | Whole-brain irradiation with hippocampal sparing and dose escalation on metastases Neurocognitive testing and biological imaging HIPPORAD a phase II prospective randomized multicenter trial NOA-14 ARO 2015 3 DKTK-ROG