The present study was carried out in TVCC, Hisar on twenty-four dogs affected with venereal granuloma. Affected dogs were divided equally into three groups viz. vincristine therapy (Group I) with 7 day cycle and doxorubicin therapy consisting two groups . Group II with 14 day cycle and group III with 21 day cycle. Blood sample collection was done at weekly interval and before administration of drug . Day 0, 7, 14 in Group I, Day 0, 7, 14, 21, 28 in Group II and Day 0, 7, 14, 21, 28, 35, 42 in Group III. Biochemical parameters viz. Alanine Amino Transferase, Alkaline Phosphatase was undertaken for study. Significant rise in serum ALP activity recorded in Group I, II, III. Distinct rise in serum ALT observed in Group I and non-significant increasing pattern recorded in Groups II and III. | Study of liver function enzymes . alanine amino transferase alkaline phosphatase in pre and post-treated dogs on chemotherapy with doxorubicin and vincristine in venereal granuloma
