The secretion of soluble factors enables communication between tumour cells and the surrounding microenvironment and plays an important role in oncogenesis. Pancreatic ductal adenocarcinoma (PDAC) is characterised by a highly reactive microenvironment, harbouring a variety of cell types, including S100A8/ S100A9-expressing monocytes. | S100A8 and S100A9 proteins form part of a paracrine feedback loop between pancreatic cancer cells and monocytes