This study was designed to evaluate the antibacterial activity of methanolic Myristica fragrans seed extract tested against four bacterial species isolated as oral pathogen. The susceptibility of these different bacterial species toward the extract of this plant seed was compared with each other. Results showed that methanolic extract exhibited antibacterial activity against gram positive bacterial species, the diameter of inhibition zone reached 28± mm against E. faecalis and 24± mm against S. mitis by extract. It is concluded that this plant can be indispensible source for secondary metabolites. | Antimicrobial susceptibility of Myristica fragrans extract against oral pathogens