Crop rotation for disease control in shrimp culture is not yet widely recognized although it is already an established practice in Agriculture, Many researchers used this practice in various species like potato cyst-nematodes. The same practice was followed by researchers. Information about crop rotation in aquaculture is very less and it is yet to be explored. Crop rotation with shrimp and tilopia indicate that the practice reduces diseases incidence in shrimp culture. In addition, crop rotation may be effective in preventing not only bacterial diseases but viral diseases as well to a certain extent as proven in agriculture. Crop rotation is a type of “ Sanitation” practice and is an integral part of plant health management. | Crop rotation as a better sanitary practice in culture of Penaeus monodon Fabricius 1798