White spot syndrome virus (WSSV) is considered as dangerous shrimp pathogen which causes severe economic loss to the shrimp production. Unavailability of protective and therapeutic measures is a serious constraint in aquaculture and till date, there is no effective preventive measure to treat WSSV. In this context, dsRNA was synthesised and used to prevent the replication of WSSV. RNA interference (RNAi) is a promising tool to fight against viral infections. | Comparative efficacy of dsRNA VP24 VP26 RR1 and WSV477 gene against WSSV infection in penaeus monodon