Docosahexaenoic acid (DHA) is a long chain n-3 polyunsaturated fatty acid that has anticancer activity. Heme oxygenase 1 (HO-1) is a potential therapeutic target due to its cytoprotective activity in cancer cells. | Sorafenib and docosahexaenoic acid act in synergy to suppress cancer cell viability A role of heme oxygenase 1