The combination of chemotherapy and L-asparaginase (L-ASP) treatment significantly increased survival rate in an adult patient with extranodal natural killer (NK)/T-cell lymphoma (NKTCL). However, hypersensitivity reactions of L-ASP in some patients limited its application. | PEG-L-CHOP treatment is safe and effective in adult extranodal NK T-cell lymphoma with a low rate of clinical hypersensitivity