Immunochemical fecal occult blood tests (iFOBTs) are increasingly used for colorectal cancer (CRC) screening. In our preceding observational study, sensitivity for detecting advanced colorectal neoplasms by iFOBT was among users of low-dose acetylsalicylic acid compared with among non-users (p = ), whereas there were only very small differences in specificity. | Clinical trial protocol of the ASTER trial a double-blind randomized placebocontrolled phase III trial evaluating the use of acetylsalicylic acid ASA for enhanced early detection of colorectal neoplasms