The present study aimed to design synthetic peptides as efflux pump inhibitors. Two synthetic peptides SG-15 and GG-15 were designed on the basis of protein sequence and structure of AcrAB-TolC a commonly expressed efflux pump of Escherichia coli (E. coli). SG-15 was designed as inner membrane protein (AcrB) blocker and GG-15 was designed as outer membrane protein (TolC) blocker. The designed inhibitors were custom synthesized. |