The combination therapy including Remdesivir and chloroquine are exceptionally successful in the control of 2019-nCoV disease in vitro. Fundamental preliminaries of Remdesivir and chloroquine repurposing in the treatment of COVID-19 have been empowering, prompting a few new trials. In this review, pathogenesis of the SARS-CoV-2 and the potential mechanism of two potent inhibitors remdesivir and chloroquine as effective therapeutic agents against COVID-19 are described. |