Vàng da ứ mật (VDUM) là tình trạng vàng da do suy giảm tổng hợp mật hoặc dòng chảy mật, đặc trưng bởi tăng bilirubin trực tiếp. VDUM do nhiều nguyên nhân gây ra, trong đó teo mật bẩm sinh (TMBS) cần được nhận biết, chẩn đoán, can thiệp sớm để có kết quả điều trị tốt nhất. Nghiên cứu này tìm hiểu nguyên nhân gây VDUM ở trẻ nhỏ và đặc điểm lâm sàng, cận lâm sàng phân biệt teo mật bẩm sinh với các nguyên nhân gây VDUM khác. | Journal of Pediatric Research and Practice Vol. 4 No. 4 2020 1-7 Research Paper Differentiating Biliary Atresia from other Causes of Cholestasis Jaundice in Infants Bui Thi Kim Oanh Nguyen Pham Anh Hoa Vietnam National Children s Hospital 18 879 La Thanh Dong Da Hanoi Vietnam Received 17 July 2020 Revised 14 August 2020 Accepted 17 August 2020 Abstract Background Purpose Cholestasis is defined as reduced bile Synthesis or biliary flow. It results of varied causes. Early detection of biliary atresia is to intervene in time and have the best outcome. The aim of this study is to find out the cholestatic etiologies in infants and differences of clinical features laboratory investigations between biliary atresia and other causes of cholestasis at Vietnam National Children s Hospital. Methods In this retrospective study 305 infants under 12 months of age with cholestasis were studied in Vietnam National Children s Hospital during 1 2017-7 2018. Demographic data duration of jaundice signs and symptoms as well as laboratory imaging liver biopsy and the causes of cholestasis were recorded divided into 2 groups BA and Non-BA. Results 305 infants 194 boys 111 girls with cholestasis and mean age of 83 22 72 10 days were included in the study. The most common causes of cholestasis were idiopathic neonatal hepatitis 33 8 biliary atresia 25 9 cytomegalovirus infection 21 6 . In BA group pale stool 100 Hepatomegaly 98 7 increasing less AST ALT more GGT level than Non-BA. AUC of GGT is lagest among AST ALT GGT and ALP. Find out GGT cutoff gt 212 05 UI l in diagnosing BA. Conclusions Biliary atresia and idiopathic neonatal hepatitis are the most common causes of infantile cholestasis. Pale stool hepatomegaly and GGT elevation gt 212 05 UI l are the reliable tests for diagnosing BA. Keywords Cholestasis Biliary atresia GGT level. ____ Corresponding author. E-mail address oanhbtk@ https 1 2 . Oanh . Hoa Journal of Pediatric .
