Investigation on the chemical constituents of ethyl acetate extract from leaves of Taxus wallichiana Zucc. (Taxaceae), collected in Ha Giang province, has resulted in the isolation of three metabolites for the first time: sciadopitysin (1), β-sitosterol (2), and isoquercitrin (3). Their structures were determined by spectroscopic methods. | HNUE JOURNAL OF SCIENCE DOI Natural Sciences 2020 Volume 65 Issue 6 pp. 110-115 This paper is available online at http CHEMICAL CONSTITUENTS OF ETHYL ACETATE EXTRACT FROM Taxus wallichiana ZUCC. TAXACEAE LEAVES COLLECTED IN HA GIANG PROVINCE Pham Huu Dien1 Pham Thi My1 and Bui Tuan Nam2 1 Faculty of Chemistry Hanoi National University of Education 2 Yen Minh High School Ha Giang province Abstract. Investigation on the chemical constituents of ethyl acetate extract from leaves of Taxus wallichiana Zucc. Taxaceae collected in Ha Giang province has resulted in the isolation of three metabolites for the first time sciadopitysin 1 β-sitosterol 2 and isoquercitrin 3 . Their structures were determined by spectroscopic methods. Keywords Taxus wallichiana Zucc. sciadopitysin isoquercitrin. 1. Introduction Taxus wallichiana Zucc. Taxaceae named as cay thong do is widely distributed in higher than 1 500 m in the mountains of Northern such as Ha Giang Cao Bang provinces and Western Vietnam such as Da Lat Lam Dong provinces 1 2 . According to Vietnam traditional medicine this plant is used for curing asthma bronchitis hiccough indigestion epilepsy ascarid 1 . The fascinating molecule taxol 3 an important antitumor and anti-leukemic drug and its close analogs have been isolated from the plant. The genus Taxus was intensively investigated for the content not only of taxoids but also of other constituents for instance biflavones 4 flavones 5 lignans 6 diterpenoids 7 . This paper describes the isolation and structural elucidation of three metabolites from the leaves of Taxus wallichiana Zucc. collected in Ha Giang province. 2. Content . Materials and methods Plant material Leaves of Taxus wallichiana Zucc. were collected in Bat Dai Son commune Quan Ba distr. Ha Giang July 2017 and identified by Prof. Dr. Do Huu Thu Institute of Ecology Natural Resource and Biology VAST Vietnam . Voucher specimens are deposited at the faculty of .
