Nghiên cứu được tiến hành nhằm cải thiện độ tan trong nước của flurbiprofen bằng cách sử dụng β-cyclodextrin (β-CD) để tạo phức hợp bao phân tử. Căn cứ vào ảnh hưởng của β-CD đến độ tan của flurbiprofen đã xác định được tỷ lệ mol tạo phức giữa hai chất này là 1:1. Qua khảo sát đã lựa chọn được phương pháp điều chế phức hợp flurbiprofen/β-CD với nhiều ưu điểm như khả năng tạo phức cao, hiệu suất thu sản phẩm tốt, quy trình đơn giản, thân thiện với môi trường. | VNU Journal of Science Medical and Pharmaceutical Sciences Vol. 36 No. 3 2020 40-48 Original Article Preparation and Characterization of Flurbiprofen β-Cyclodextrin Inclusion Complex Nguyen Thi Thanh Binh Ho Thi Quynh Xuan Nguyen Thi Hai Yen VNU School of Medicine and Pharmacy 144 Xuan Thuy Cau Giay Hanoi Vietnam Received 08 July 2020 Revised 14 July 2020 Accepted 15 July 2020 Abstract This study aims to ameliorate the water solubility of flurbiprofen by using β-cyclodextrin β-CD . The drug ligand 1 1 M M stoichiometry was determined based on the effect of β-CD on the solubility of flurbiprofen. Several methods of preparing flurbiprofen β-CD inclusion complex were investigated and a solvent method using hot water to dissolve the starting materials was selected. The selected method showed a lot of advantages such as high complexing ability good product yield simple and eco-friendly process. The obtained product was characterized using various analytical techniques such as high-performance liquid chromatography differential scanning calorimetry Fourier transform infrared spectroscopy X-ray diffraction and scanning electron microscopy. The product had a predominantly amorphous form with clathrate particles of about 2-7 µm in size irregular edges and rough surfaces. The study results show that in the complexing process flurbiprofen replaced water molecules located in the conical cavity of β-CD. The complex contained flurbiprofen by mass with water solubility at 37 C was 1 100 µg ml. The results also show that the complexing with β-CD significantly improved the water solubility of flurbiprofen by both speed and level. Keywords Flurbiprofen β-cyclodextrin inclusion complex water solubility preparation characterization. ____ Corresponding author. E-mail address binhnguyen@ https 2588-1132 40 . Binh et al. VNU Journal of Science Medical and Pharmaceutical Sciences Vol. 36 No. 3 2020 40-48 41 Điều chế và mô tả một số .
