Sperm-mediated gene transfer (SMGT) is a transgenic technique involves transfer of the genes based on the spermability to bind spontaneously and internalize the exogenous DNA, and transport it into an oocyte during fertilization to produce genetically modified animals. Spermatozoa play a major role in transgenesis in virtually all species. Their ability to take up exogenous DNA molecules to transmit novel genetic information to the offspring after fertilization can be exploited. |
