Nghiên cứu này đánh giá hoạt tính ức chế enzyme α-glucosidase của dịch chiết từ 7 loài rong nâu (Colpomenia sinuosa, Padina australis, Sargassum aquifolium, Sargassum mcclurei, Sargassum duplicatum, Sargassum polycystum và Sargassum swartzi). Kết quả nghiên cứu cho thấy tất cả các mẫu rong nghiên cứu đều có hoạt tính ức chế enzyme α-glucosidase, với giá trị IC50 dao động từ 154,27 đến 426,27 µg/mL. Mời các bạn tham khảo chi tiết nội dung bài viết này. | 90 Trường Đại học Nông Lâm TP. Hồ Chí Minh Alpha-glucosidase inhibitory activity of some brown seaweeds collected in Nha Trang bay Khanh Hoa province Han T. Nguyen1 Yen T. P. Nguyen2 3 amp Duong T. H. Ngo2 1 Faculty of Food Technology Nha Trang University Nha Trang Vietnam 2 Insitute of Biotechnology and Environment Nha Trang University Nha Trang Vietnam 3 Quality Management Department of Agriculture Forestry and Fisheries Lam Dong Vietnam ARTICLE INFO ABSTRACT Research Paper Diabetes has become a global problem in recent years. Inhibition of α-glucosidase is one of the effective approaches to control the post- Received December 16 2019 prandial blood gluccose and thereby mananging diabetes. This study Revised January 28 2020 evaluated inhibitory activity of seven brown seaweed extracts Colpomenia Accepted February 25 2020 sinuosa Padina australis Sargassum aquifolium Sargassum mcclurei Sargassum duplicatum Sargassum polycystum và Sargassum swartzi Keywords against α-glucosidase. The results indicated that all seaweed extracts inhibited enzyme activity with the IC50 values ranging from to µg mL. The seaweed Sargassum mcclurei showed the highest α-glucosidase inhibitor α-glucosidase inhibitory activity. The effects of extraction conditions Brown seaweeds and extraction solvent fractions on α-glucosidase inhibitory activity of Diabetic Sargassum mcclurei were investigated. The suitable extraction conditions Extraction conditions were found to be the solid to liquid ratio g mL of 1 40 the extraction Sargassum mcclurei time of 60 min and the extraction temperature of 60o C. The ethyl acetate extracted fraction showed the highest α-glucosidase inhibitory activity Corresponding author compared with other fractions. Nguyen The Han Email hannt@ Cited as Nguyen H. T. Nguyen Y. T. P. amp Ngo D. T. H. 2020 . Alpha-glucosidase inhibitory activity of some brown seaweeds collected in Nha Trang bay Khanh Hoa province. The Journal of Agriculture and .
