Bài viết trình bày khảo sát đáp ứng sinh hóa và virus sau 12 tháng điều trị Entecavir ở bệnh nhân viêm gan virus B mạn, khảo sát biến đổi về độ xơ hoá gan sau điều trị và mối liên quan với các đặc điểm sinh hóa và virus. | 1 NGHIÊN CỨU ĐÁP ỨNG SINH HÓA VIRUS VÀ ĐỘ ĐÀN HỒI GAN Ở BỆNH NHÂN VIÊM GAN VIRUS B MẠN SAU 12 THÁNG ĐIỀU TRỊ ENTECAVIR Nguyễn Viết Thịnh Trần Văn Huy ABSTRACT Background Chronic hepatitis B can lead to serious complications such as cirrhosis and liver cancer. The perspective of chronic hepatitis B treatment has also changed which is taking antiviral drugs to inhibit viral replication process in a sustainable way normalizing the liver en- zymes and clinical features seroconversion and improvement in the liver histology pre- venting the progression of the disease reducing the rate of complications and mortality. Assessing the histology by liver elastography by Fibroscan has several advantages when compared with liver biopsy and can indicate repeatedly therefore it can help us to follow up the treatment of chronic hepatitis B. Our thesis aims to study the biochemistry virus and liver elasticity responses in patients with chronic hepatitis B after 12 months of entecavir treatment. To evaluate the virologic response efficacy histological improvement and monitor the treatment of chronic hepatitis b. Methods Prospective open non-controlled study. 75 patients over 16 years old was diagnosed with chronic hepatitis B and treated at the Pasteur Institute in Ho Chi Minh City. Patients have been diagnosed with chronic hepatitis B with elevated ALT gt 2 x UNL and HBeAg antiHBe quantitative HBV-DNA tests serum creatinine and Fibroscan to assess the degree of fibrosis according to the METAVIR classification. Study subjects used only a single drug which is Entecavir mg orally 2 hour after meal or at fast during 12 months. The biochemical tests ALT HBeAg AntiHBe quantitative HBV-DNA were done after 3 6 9 and 12 months. Fibroscan is evaluated after 6 and 12 months. The collected data were pro- cessed in SPSS statistical software standard deviation SD the mean Percentage s- tical significance is p 2 Change in the degree of liver fibrosis after treatment and relationship with
