Based on the above scientific bases and arguments, I conduct a research project to search for bioactive alkaloids while also researching new activities from alkaloids, thereby increasing cumulative growth culture. Content of alkaloids by adding elicitors. | MINISTRY OF EDUCATION AND VIET NAM ACADEMY OF TRAINING SCIENCE AND TECHNOLOGY GRADUATE UNIVERSITY OF SIENCE AND TECNOLOGY ----------------------------- Name Tran Thu Trang PROJECT NAME RESEARCH ON INCREASING THE ACCUMULATION OF BIOACTIVE ALKALOID COMPOUNDS FROM EURYCOMA LONGIFOLIA JACK BREEDED ON 20-LITER BIOREACTOR Major Biochemistry Code SUMMARY OF BIOLOGICAL DOCTORAL THESIS Ha Noi-2020 1 The work was completed in Graduate university of sience and techology- Viet Nam academy of science and technology Science instructor 1 TS. Chu Nhatt Huy Science instructor 2 PGS. TS. Pham Bich Ngoc Reviewer 1 Reviewer 2 Reviewer 3 . The thesis will be defended in front of the Academy Thesis Evaluation Council meeting at Graduate university of sience and techology- Viet Nam academy of science and technology at . hour . date . month . year 201 . The thesis can be found at - Library of Academy of Science and Technology -Vietnam National Library 2 PREAMBLE The urgency of the subject Eurycoma longifolia Jack is a common medicinal plant in our country mainly distributed in the Central provinces Kon tum Dong Nai Phu Quoc and Bai Tu Long National Park. E. longifolia is used to improve health increase testosterone in men has strong anti-inflammatory activity good anti-cancer and some other effects such as malaria treatment anti- osteoporosis diabetes . research work on E. longifolia shows that the plant contains many alkaloid active substances that are valuable in anti-malarial anti-inflammatory carcinogenic and invigorating cancer. Currently is being over-exploited in the wild due to the increasing demand for herbal use. Moreover is difficult to grow and replicate with the time to harvest quality roots takes at least 5-6 years leading to difficulties in raw materials for pharmaceutical production. To date root culture is considered a potential alternative to stable collection of large amounts of clean biomass in a short period of 30-40 days as
