Study on chemical constituents of two Knema species including Knema pachycarpa and Knema saxatilis growing in Vietnam; evaluate cytotoxic and cetylcholinesterase enzyme inhibitory activitiesof isolates to find out bioactive compounds. | MINISTRY OF EDUCATION VIETNAM ACADEMY OF AND TRAINING SCIENCE AND TECHNOLOGY GRADUATE UNIVERSITY OF SCIENCE AND TECHNOLOGY ----------------------------- TRAN HUU GIAP STUDY ON CHEMICAL CONSTITUENTS AND BIOLOGICAL ACTIVITIES OF KNEMA PACHYCARPA AND KNEMA SAXATILIS Major Organic chemistry Code SUMMARY OF CHEMISTRY DOTORAL THESIS Ha Noi - 2020 This thesis was completed at Graduate university of Science and Technology - Vietnam Academy of Science and Technology Advisor 1 Dr. Le Nguyen Thanh Advisor 2 Prof. Dr. Nguyen Van Hung Reviewer 1 Reviewer 2 Reviewer 3 The dissertation will be defensed before the Evaluation Council of the doctoral dissertation at the Academy meeting at the Academy of Science and Technology - Vietnam Academy of Science and Technology at . hours . date . month 2020. The thesis can be found at - The Library of Graduate University of Science and Technology Vietnam Academy of Science and Technology. - National Library of Vietnam. INTRODUCTION 1. The urgency of the thesis The genus Knema Myristicaceae is commonly found in tropical countries like Asia Africa and Australia. Knema plants have been used in the traditional medicine for treatment of pimples sores and skin diseases. Previous chemical studies of Knema species have reported the isolation of anacardic acids cardanols resorcinols acetophenones lignans stilbene and flavonoids. Knema plant exhibited antibacterial anti-inflammatory antioxidant cytotoxic and acetylcholinesterase inhibitory activities. However there are few researches on the chemical components and biological activities of Knema species growing in Vietnam. In the active screening of plant species in Vietnam search for biologically active substances we found several species Knema express cytotoxic activity and inhibition of enzyme acetylcholinesterase Ethyl acetate extract of Knema pachycarpa exhibits enzyme inhibitory activity acetylcholinesterase 100 at a concentration of 10 μg ml and inhibits 44 of cell human epidemoid .
