Isolation and screening for Vietnam antimicrobial marine-derived actinobacteria strains; isolation and structure elucidation of compounds from 2 promising isolated actinobacteria strains; determination the antimicrobial activities of isolated compounds. | MINISTRY OF EDUCATION VIETNAM ACADEMY AND TRAINING OF SCIENCE AND TECHNOLOGY GRADUATE UNIVERSITY SCIENCE AND TECHNOLOGY ----------------------------- CAO DUC TUAN PROJECT STUDY ON ANTIMICROBIAL SECONDARY METABOLITES ISOLATED FROM SELECTED MARINE- DERIVED ACTINOBACTERIA STRAINS BELONG TO STREPTOMYCES GENUS Major Organic Chemistry Code SUMMARY OF ORGANIC CHEMISTRY DOCTORAL THESIS HA NOI 2020 This project was completed at Graduate University Science and Technology Vietnam Academy of Science and Technology. Scientific Advisor 1 Assoc. Prof. Doan Thi Mai Huong Scientific Advisor 2 Dr. Le Thi Hong Minh Reviewer 1 Reviewer 2 Reviewer 3 . The thesis will be defended at Graduate University of Science and Technology Vietnam Academy of Science and Technology at The thesis can be found at - The library of the Graduate University of Science and Technology Vietnam Academy of Science and Technology. - The National Library of Vietnam. 1 INTRODUCTION 1. Basic of the thesis Natural resources have been used as drugs additives and poisons for a long time Marderosian 1969 . To date natural products most of them from terrestrial play a major role in pharmaceutical industries Harvey 2000 . Although oceans accounted for about 70 of earth surface proved to be very high biodiversity researches on marine natural products only started recently Fattorusso 2012 . There are over 30 000 marine natural products known to the public with diverse chemical structures and biological activities Hu 2011 . Some reported marine natural products had structure similar to that of microorganism. It suggested that microorganism may involve in the biosynthesis of these compounds or microorganism might be the production source Molinski 2009 . Moreover one of the major advantages of marine microbial research is that it only requires a small amount of natural collected marine samples. Laboratory isolation fermentation can help to produce enough material for further researches. Vietnam situated in the .
