The aims of the dissertation are: Isolation and purification of the main chemical constituents of the plant Centella asiatica (L.) Urban collected from various regions in Vietnam; synthesis of new derivatives of asiatic acid and madecassic acid obtained from C. asiatica. | VIETNAM ACADEMY OF SCIENCE AND MINISTERY OF TECHNOLOGY EDUCATION AND GRADUATE UNIVERSITY OF SCIENCE AND TRAINING TECHNOLOGY VO THI QUYNH NHU STUDY ON THE ISOLATION CHEMICAL TRANSFORMATION AND BIOLOGICAL ACTIVITIES OF TRITERPENOIDS FROM CENTELLA ASIATICA L. URBAN - APIACEAE Scientific Field Organic Chemistry Classification Code 62 44 01 14 DISSERTATION SUMMARY HA NOI - 2017 The dissertation was completed at Institute of Chemistry Vietnam Academy of Science and Technology Scientific Supervisors 1. Prof. Dr. Sc. Tran Van Sung Institute of Chemistry - Vietnam Academy of Science and Technology 2. Dr. Tran Van Loc Institute of Chemistry - Vietnam Academy of Science and Technology 1st Reviewer . . . nd 2 Reviewer . . . 3rd Reviewer . . . The dissertation will be defended at Institute of Chemistry Vietnam Academy of Science and Technology 18 Hoang Quoc Viet Cau Giay District Ha Noi City. At . hour . date . month .2017. The dissertation can be found in National Library of Vietnam and the library of Institute of Chemistry Vietnam Academy of Science and Technology. I. INTRODUCTION 1. Background Nowadays it is necessary to search for interesting active compounds and develop them to new drugs. Besides active natural products study on synthesis of active derivatives from compounds isolated from plant sources is one of the most effective ways to search for interesting active compounds. Centella asiatica L. Urban Apiaceae is a tropical medicinal plant native to South and Southeast Asian countries including Vietnam. This plant has been reported to own a wide range of biological activities such as wound healing anti- inflammatory antipsoriatic antiulcer hepatoprotective anticonvusant sedative immunostimulant cardioprotective antidiabetic cytotoxic antitumor antiviral antibacterial anti-insecticidal antifungal and antioxidant activities. It also has been used for the treatment of lepra and venous deficiencies. The plant Centella asiatica contains several classes of natural .
