Successful synthesis of GdPO4:Tb3+ nanorods and Gd2O3:Eu3+ nanospheres; coating GdPO4:Tb3+ nanorods and Gd2O3:Eu3+ nanospheres with a silica shell, functionalizing with NH2 functional group, conjugating with anti-venom and anti-CEA antibodies for further biomedical applications. | MINISTRY OF EDUCATION VIETNAM ACADEMY OF AND TRAINING SCIENCE AND TECHNOLOGY ----------------------------- GRADUATE UNIVERSITY SCIENCE AND TECHNOLOGY PHAM THI LIEN RESEARCH ON THE SYNTHESIS PROPERTIES OF GdPO4 Tb3 AND Gd2O3 Eu3 NANOMATERIALS ORIENTED FOR BIOMEDICAL APPLICATIONS Major Optical optoelectronic and photonic materials Code 62 44 01 27 SUMMARY OF DOCTORAL THESIS IN MATERIAL SCIENCE Ha Noi - 2020 The thesis has been completed at Graduate University of Science and Technology - Vietnam Academy of Science and Technology Science supervisors 1. Dr. Nguyen Thanh Huong 2. Prof. Dr. Le Quoc Minh Reviewer 1 Reviewer 2 Reviewer 3 The thesis was defended at Evaluation Council held at Graduate University of Science and Technology - Vietnam Academy of Science and Technology on 2020. Thesis can be further referred at - The Library of Graduate University of Science and Technology. - National Library of Vietnam. 1 INTRODUCTION 1. 1. The necessity of the thesis Luminescent nano-materials containing Rare Earth RE-NP have received much attention in recent years. Notably the materials GdPO4 Tb3 and Gd2O3 Eu3 become the critical research tool for the wide- ranging biomedical applications in the diagnosis and treatment of human disease. Magnetic resonance imaging MRI examination and especially live-cell fluorescence microscopy are widely utilized in hospitals and clinics. In Vietnam many research groups have focused on the synthesis of luminescent materials as photonic biomarkers creating the analytical tool for assessing the quality of biologicals foods and vaccines. However most of the biomedical applications are primarily based on a single functional tool . either luminescent material as a biomarker or magnetic material as a hyperthermia agent for enhancing the contrast of image. Therefore it is urgent to develop a multifunctional tool especially simultaneously possessing fluorescence and magnetic properties in a single system to improve the efficiency of diagnostic and
