Nghiên cứu được thực hiện với mục đích phân tích được các cặp tương tác thuốc chống chỉ định thường gặp trong thực hành lâm sàng tại 3 bệnh viện Tỉnh Quảng Ninh dựa trên dữ liệu hồi cứu kê đơn lấy từ BHYT Tỉnh. | VNU Journal of Science Medical and Pharmaceutical Sciences Vol. 37 No. 1 2021 48-56 Original Article Evaluation of Contraindicated Drug-Drug Interactions in Electronic Health Insurance Data at 3 Hospitals in Quang Ninh Province through Navicat Software Nguyen Thanh Hai1 Phung Thi Thu Ha2 Do Thanh Long1 Duong Thi Van1 Nguyen Xuan Bach3 1 Hanoi University of Pharmacy 13-15 Le Thanh Tong Hoan Kiem Hanoi Vietnam 2 Social insurance at Quang Ninh Province Tran Hung Dao Ha Long Quang Ninh Vietnam 3 VNU University of Medicine and Pharmacy 144 Xuan Thuy Cau Giay Hanoi Vietnam Received 16 October 2020 Revised 25 January 2021 Accepted 25 January 2021 Abtract This study analyzes contraindicated drug-drug interactions stored in electronic health insurance data at three hospitals in Quang Ninh Province based on the list of concentrated contractor drugs applied in Quang Ninh province within the scope of payment of the Health Insurance Fund in 2018. The researchers developed a list of 112 pairs of the contraindicated drug-drug interactions to serve as a reference to determine the frequency of contraindicated drug-drug interactions over 519 500 medical records and 1 254 099 prescriptions at 3 hospitals in Quang Ninh province. Twenty-six contraindicated drug-drug interactions were found over 297 medical records and 789 prescriptions 5 pairs with the highest frequency are Amiodarone-Amitriptyline Amiodarone-Moxifloxacin Amiodarone-Colchicine Levodopa -Sulpiride and Amiodarone- Haloperidol. Medical reccords with contraindicated drug-drug interactions were found in 13 different departments or interdisciplinary departments at all the three hospitals of which the highest rates were found in Intensive Care Unit and Emergency Departments Endocrinology Departments and Cardiology Pediatric Departments . The study also analyzed 26 pairs of common contraindicated drug-drug interactions in clinical practice based on retrospective data on drugs prescribed at the 3 hospitals
