Our goal was to simulate Parkinson’s disease (PD) development in time with the help of granular computing (GrC) methods (Pawlak, 1991; Zadeh, 2002). As PD-related neurodegeneration (ND) starts ∼20 years before the first symptoms and during this period of time, the ND process is effectively compensated by brain plasticity, each patient’s PD progressions are different. |