Đánh giá hiệu quả bước đầu điều trị u nguyên bào võng mạc bằng phương pháp truyền hóa chất qua đường động mạch

U nguyên bào võng mạc (UNBVM) là khối u ác tính nội nhãn hay gặp nhất ở trẻ em. Truyền hóa chất qua đường động mạch dưới hướng dẫn của chẩn đoán hình ảnh là một phương pháp mới trong điều trị những khối UNBVM thể nội nhãn nhằm mục tiêu bảo tồn nhãn cầu tối đa. Bài viết trình bày đánh giá hiệu quả bước đầu và mức độ an toàn điều trị UNBVM bằng phương pháp truyền hóa chất qua đường động mạch. | ĐÁNH GIÁ HIỆU QUẢ BƯỚC ĐẦU NGHIÊN CỨU KHOA HỌC ĐIỀU TRỊ U NGUYÊN BÀO VÕNG MẠC SCIENTIFIC RESEARCH BẰNG PHƯƠNG PHÁP TRUYỀN HÓA CHẤT QUA ĐƯỜNG ĐỘNG MẠCH Evaluation the initial outcomes in treatment of retinoblastoma by using intra-arterial chemotherapy Hoàng Thị Kim Khuyên Vũ Đăng Lưu Nguyễn Quang Anh Nguyễn Tất Thiện Phạm Minh Thông SUMMARY Retinoblastoma is the most common malignant tumor eye tumor in children which can cause blindness and even mortality if diagnosis and treatment are delayed. Intra-arterial chemotherapy IAC under the guidance of radiology is a new method for the treatment of intraocular retinoblastomas. Purpose To evaluate the initial outcomes and safety of intra-arterial chemotherapy in treatment retinoblastoma. Materials and Methods 15 patients diagnosed with intraocular retinoblastoma were clinically and subclinically examined made imaging diagnosis ultrasound and MRI then define retinoblastoma stage by the 2003 international classification whether or not it has been combine with other methods and then is indicated for IAC from October 2017 to June 2019. Each intervention is 3-4 weeks apart. The patients were followed immediately after treatment for the clinical symptoms and after 3-4 weeks after intervention to reassess the tumors and treatment results. Results 15 patients including 6 males and 9 females corresponded to 15 study eyes with an average 35 5 20 8 age of months 11 months to 84 months . According to the International classification there are 3 patients 20 of group B retinoblastoma 6 patients 40 of group C retinoblastoma 6 patients 40 of group D retinoblastoma no patients in group A and group E. The total number of tumors in 15 eyes is 27 which has been treated with intravenous chemotherapy combined with one or two local treatments laser and cryotherapy . The total number of interventions was 29 each patiens was treated from 1 to 3 times. As a result 4 patients 26 7 had good treatment results 8 patients 53 3 had average .