Trong thực hành kê đơn cho bệnh nhân, việc phát hiện nhanh các cặp tương tác thuốc bất lợi và đưa ra biện pháp xử trí kịp thời khi kê đơn đóng vai trò vô cùng quan trọng trong việc đảm bảo sử dụng thuốc an toàn, hợp lý. Đối tượng và phương pháp nghiên cứu: Tất cả các đơn kê có cảnh báo tương tác thuốc (TTT) của bệnh nhân điều trị nội trú từ 01/01/2021 đến 31/3/2021 trên báo cáo lưu vết của phần mềm HIS tại Khoa dược, Bệnh viện Đa khoa tỉnh Lào Cai. | VNU Journal of Science Medical and Pharmaceutical Sciences Vol. 37 No. 2 2021 70-76 Original Article Effectiveness of the Management of Drug-drug Interactions in Inpatients through the Drug Interaction Warning System and Clinical Pharmacy Activity at Lao Cai General Hospital Nguyen Thi Thuy An1 Pham Van Thinh1 Nguyen Thanh Hải2 Nguyen Xuan Bach3 1 Lao Cai General Hospital Chieng On Binh Minh Lao Cai Vietnam 2 Hanoi University of Pharmacy 13-15 Le Thanh Tong Hoan Kiem Hanoi Vietnam 3 VNU University of Medicine and Pharmacy 144 Xuan Thuy Cau Giay Hanoi Vietnam Received 18 April 2021 Revised 23 April 2021 Accepted 23 April 2021 Abstract In prescribing practice for inpatients quickly detecting pairs of drug-drug interactions DDIs and providing prompt management when prescribing is of utmost importance in ensuring safe and rational use of drugs. Subjects and research methods All prescriptions with DDIs warnings for inpatients from 1 1 2021 to 31 3 2021 on the residue reporting system at Lao Cai General Hospital. The research is designed as a cohort study. Results In 3 months of implementing DDIs surveillance on the system of reporting there were 214 times of DDIs occurring in 157 inpatients of which 2 were contraindicated DDIs and 212 severe DDIs. Patients with DDIs have the mean age and number of diseases respectively years and diseases . 2 patients with contraindicated DDIs of a clarithromycin-lovastatin pair received direct feedback from pharmacists to agree to cancel the prescription Patients with severe DDIs are also discussed by pharmacists to agree on the most appropriate management for each patient such as of clinical supervision of replacement medicine of following up more tests of stopping using drugs. Conclusion The DDIs warning system and clinical pharmacy activity have managed all pairs of DDIs that often occur on inpatients at Lao Cai General Hospital. Keywords Drug interaction warning system clinical pharmacy .
