The objectives of the thesis: Isolation and determination of chemical structures of the isolated compounds from the leaves of Excoecaria agallocha L. and Excoecaria cochinchinensis Lour.; studied the cytotoxic, anti-inflammatory, and antimicrobial activities of the isolated compounds to find the bioactive compounds. | 1 MINISTRY OF EDUCATION VIETNAM ACADEMY OF AND TRAINING SCIENCE AND TECHNOLOGY GRADUATE UNIVERSITY SCIENCE AND ECHNOLOGY - Lai Hop Hieu STUDY ON CHEMICAL CONSTITUENTS AND BIOLOGICAL ACTIVITIES FROM THE LEAVES OF EXCOECARIA AGALLOCHA L. AND EXCOECARIA COCHINCHINENSIS Lour. Major Organic chemistry Code SUMMARY OF CHEMISTRY DOCTORAL THESIS Hanoi 2021 2 This thesis was completed at Graduate University Science and Technology - Vietnam Academy of Science and Technology Adviser 1 Prof. Dr. Ngo Dai Quang Adviser 2 Dr. Nguyen Van Thanh 1st Reviewer . 2nd Reviewer . 3rd Reviewer . The thesis will be defended at Graduate University of Science and Technology - Vietnam Academy of Science and Technology at hour date month 2021. Thesis can be found in - The library of the Graduate University of Science and Technology Vietnam Academy of Science and Technology - National Library 1 INTRODUCTION 1. The urgency of the thesis Throughout human history marine microorganisms and natural plants have become potential sources in the discovery of novel drugs for the treatment of human diseases. Nowadays more than 70 of anti- cancer drugs in the market are derived from natural products or synthesized based on the structure of natural compounds. Besides cancer which is a major issue of concern for scientists the emergence of antibiotic drug resistance is also a big threat to human health worldwide. Antibiotic drug resistance occurs when microorganisms such as viruses fungi or parasites change their mechanism of action in response to the existing antimicrobial treatments. Several factors contribute to antibiotic resistance such as the overuse misuse of antibiotics and the self-medication with antibiotics. The important role of natural bioactive compounds has been investigated from traditional medicine to modern medicine. Their value is not only for direct use as a medicine but also as a structure lead compound for the discovery and development of new drugs. In an attempt to .
