Practical questions put forward by clinicians in the past have been researched and settled in the thesis. The AD diagnosis is completely based on clinics and the implementation of clinical tests for the diagnosis work depends on assessors’ subjectivity. Therefore, the development of MRI techniques shall help clinicians make diagnosis more quickly and objectively. | MINISTRY OF EDUCATION AND TRAINING MINISTRY OF HEALTH HANOI MEDICAL UNIVERSITY NGOC TRAN VAN RESEARCH INTO MORPHOLOGICAL FEATURES AND SOME SPECIAL PULSE SEQUENCE ON BRAIN MAGNETIC RESONANCE IN ALZHEIMER PATIENTS Specialism Radiology Diagnosis Code 62720166 SUMMARY OF THESIS ON DOCTOR OF MEDICINE HANOI 2021 Research completed at HANOI MEDICAL UNIVERSITY Scientific instructors ASSOC. PROF amp PHD THANG PHAM ASSOC. PROF amp PHD LUU VU DANG Defender 1 Defender 2 Defender 3 The Thesis shall be defended at the PhD Council of Medicine at Hanoi Medical University At on 2021 The Thesis can be found at - National Library - Library of Hanoi Medical University 1 INTRODUCTION Alzheimer disease is the degeneration pathology of the central nerve system with features of gradually increasing but unrecoverable progression. It causes the memory loss cognitive disorder and changes in behaviors which affects patients occupation and social lives. Current criteria for Alzheimer disease is mainly diagnosed based on such three globally accepted current clinical criteria as DSM V1 ICD X2 NINCDS-ADRDA3. Magnetic resonance images MRI can be considered as paraclinical tests relevant to Alzheimer disease diagnosis as they allow to precisely measure the brain weight in 3 directions 3D especially the size of the hippocampus and related areas5 as well as image changes in AD patients based on their diffusion spectro and perfusion. Therefore the development of image diagnosis methods by MRI for Alzheimer disease in the pre-clinical stage is very vital and pressing especially for the 3 pulse sequences diffusion spectro and perfusion. This has brought about a positive imaging method in AD diagnosis. Some researchers in Vietnam have initially studied the MRI morphology. However none of them has utilized such pulse sequences as diffusion spectro and perfusion to quantify changes in brain images in AD patients. We have conducted the theme Research into morphological features and some special pulse .
