In this paper, antidiabetic activities of glucomanno-oligosaccharides (GMO) were in vitro and in vivo investigated. Treatment with 100 μg/ml and 50 μg/ml of GMO for 1 hour caused and phosphorylation of AMPK, respectively. Oral administration of GMO (6 g/kg-1 of body weight day-1 ) lowered blood glucose levels (p |