Copper/periodic mesoporous organosilica (Cu/PMO) nanocomposites provided a highly active, reusable, globular, solid-phase catalyst for click chemistry. The reaction proceeds by mixing organohalides, sodium azide, alkyne, and the catalyst in an aqueous medium to afford the desired products. The cost efficiency and recyclability of the catalyst up to six runs without appreciable loss of activity and high yields of products make this procedure greener. | Turkish Journal of Chemistry Turk J Chem 2017 41 700 709 http chem ITAK c TUB Research Article doi kim-1610-57 Nanocomposite copper metal as an efficient heterogeneous catalyst in click synthesis of 1 2 3-triazoles in aqueous media Vajihe NEJADSHAFIEE Hossein NAEIMI Department of Organic Chemistry Faculty of Chemistry University of Kashan Kashan Iran Received Accepted Published Online Final Version Abstract Copper periodic mesoporous organosilica Cu PMO nanocomposites provided a highly active reusable globular solid-phase catalyst for click chemistry. The reaction proceeds by mixing organohalides sodium azide alkyne and the catalyst in an aqueous medium to afford the desired products. The cost efficiency and recyclability of the catalyst up to six runs without appreciable loss of activity and high yields of products make this procedure greener. Key words Mesoporous organosilica nanocomposites click reaction 1 2 3-triazoles catalyst 1. Introduction Click chemistry has become one of the most important concepts in modern chemistry focusing on efficiently creating molecular diversity from readily available starting materials under simple reaction conditions. 1 Copper I -catalyzed organoazide alkyne cycloaddition CuAAC 2 was one of the most credible click-type reactions within the concept of click chemistry. 3 5 This reaction has enabled the practical and efficient preparation of 1 2 3-triazoles from a wide range of substrates with excellent selectivity that cannot be prepared via traditional Huisgen uncatalyzed thermal approaches. 6 Triazoles have attracted considerable interest recently because of their wide usefulness. Among them 1 2 3-triazoles have received much attention and have been used in variety of synthetic and medicinal chemistry applications such as drug discovery 7 material science 8 and bioconjugation. 9 In this regard heterogeneous catalysis emerges as an important tool and has been frequently .
