The significant development in the construction of microscale cell culture platforms and the interest in bioanalytical analysis have recently resulted in the emergence of a new concept of ‘organ-on-a-chip’ systems. Organon-a-chip is a new three-dimensional (3D) in vitro microfabricated unit that contains a multichannel microfluidic cell culture. Even if many informative and useful data are obtained from animal models and in vitro assays, they are still limited for extrapolation to human systems during drug design and development. Only about 1 out of 10,000 compounds is processed in clinical trials for final approval. |
