2-Substituted 8-propargyloxyquinoline derivatives have been synthesized from 2-substituted-8-hydroxyquinolines by O-propargylation method (30%–98% yields). The newly synthesized compounds were tested for in vitro antioxidant activities such as DPPH radical scavenging, ferrous chelating, and reducing power activities. The maximum radical scavenging () and reducing power activities were obtained from 1 and maximum ferrous chelating effect was obtained from 6 () at the concentration of 500 µg/mL. To indicate DNA binding activity of the complexes calf thymus DNA was used. |
