The present study reports the efficient synthesis and computational studies of the structural and electronic properties of some interesting substituted phenol derivatives. Efficient and versatile procedures to synthesize a series of diaryl ether derivatives (2a–2c, 4a–4h) and bis-arylated products (5a–5c) are described. In this manuscript, using the commercially available starting material 1 and 3, a 1-step approach was developed by means of Cu(II)-mediated Chan–Lam and Pd-catalyzed Suzuki cross-coupling reactions to synthesize diaryl ether and bis-arylated products with moderate to good yields. |
