Cyclic voltammetry (CV) was performed on tamoxifen (tam) using different electrodes and in various acidic electrolytes containing 10% v v−1 methanol (MeOH). Tam oxidation was found to be most favorable using mol L−1 H2SO4. To investigate the mechanism, we performed chronoamperometry, CV at different scan rates, differential pulse anodic voltammetry (DPAV), and electrochemical impedance spectroscopy on tam-covered glassy carbon electrodes (GCEs). The electrode area, diffusion coefficient, and surface concentration (Γ) of tam were calculated to be cm2, × 10−6 cm2 s−1 , and × 10 −10 mol cm−2 respectively. Then the effects of different parameters on the DPAV were optimized. The best conditions were v v−1 cMeOH, mol L−1 H2SO4 , deposition potential V, deposition time 30 s, and GCE rotating rate 400 rpm. |
