Mục tiêu nghiên cứu: xác định tỉ lệ di căn hạch và tìm hiểu mối liên quan giữa tình trạng di căn hạch và một số đặc điểm giải phẫu bệnh trong ung thư biểu mô (UTBM) tuyến vú thể đặc biệt. Đối tượng và phương pháp nghiên cứu: Nghiên cứu mô tả cắt ngang trên 200 bệnh nhân UTBM tuyến vú thể đặc biệt tại Trung tâm Giải phẫu bệnh - Sinh học phân tử, Bệnh viện K từ 08/2020 đến 04/2021. | VNU Journal of Science Medical and Pharmaceutical Sciences Vol. 37 No. 4 2021 45-53 Original Article Factors Associated with Lymph Node Metastasis in Special Types of Invasive Breast Cancer at National Cancer Hospital in the Period of 2018 - 2021 Nguyen Thi Quynh1 Trinh Quang Dien2 1 Hanoi Medical University 1 Ton That Tung Dong Da Hanoi Vietnam 2 National Cancer Hospital 30 Cau Buou Tan Trieu Thanh Tri Hanoi Vietnam Received 19 May 2021 Revised 09 June 2021 Accepted 08 September 2021 Abstract This paper assesses the rate of lymph node metastasis and the correlation between lymph node metastasis and some pathological characteristics in special types of invasive breast cancer. In the paper a descriptive cross sectional study was conducted on 200 patients with special types of invasive breast cancer at the Institute of Molecular Biology and Pathology - National Cancer Hospital from August 2020 to April 2021. The study results show that 32 of the 200 cases had nodal metastases. The factors associated with the increased risk of lymph node metastasis were of histological types invasive lobular invasive micropapillary carcinomas p high tumour grade p the presence of lymphovascular invasion p tumor-infiltrating lymphocytes TILs lt 10 p the presence of tumor necrosis p Her-2 neu overexpression p Ki-67 20 p HER2-positive breast cancer p . Overall the rate of lymph node metastasis was 32 . Histological type tumour grade the presence of lymphovascular invasion TILs tumor necrosis Her-2 neu and Ki-67 expression and molecular subtype were factors related to lymph node metastasis in special types of invasive breast cancer. Keywords Lymph node metastasis invasive breast cancer special types. _ Corresponding author. E-mail address quynh95hmu@ https 2588-1132 45 46 N. T. Quynh T. Q. Dieu VNU Journal of Science Medical and Pharmaceutical Sciences Vol. 37 No. 4 2021 45-53 Khảo sát một số yếu tố liên
